If you’re craving a homey, comforting meal that combines the best of two classic favorites, then you absolutely have to try this Meatloaf Mac Casserole Recipe. It’s that magical dish where hearty, flavorful meatloaf meets creamy, cheesy macaroni in one irresistible casserole. Each bite offers a perfect balance of tangy barbecue glaze, tender ground beef, and gooey cheese that’s sure to have everyone asking for seconds. This recipe takes simple, down-to-earth ingredients and transforms them into a true made-from-the-heart dinner that feels like a warm hug on a plate.

Ingredients You’ll Need
These ingredients are straightforward yet essential for creating the luscious layers and rich flavors in the Meatloaf Mac Casserole Recipe. Each item brings something special to the dish, whether it’s the tangy brightness of ketchup or the smooth creaminess of cheese soup, ensuring every mouthful is full of comforting goodness.
- 1 cup ketchup, separated: Adds sweetness and acidity to complement the savory beef and sauces.
- 1 cup barbecue sauce: Brings smoky, tangy notes that give the meatloaf its signature flavor boost.
- 2 pounds ground beef (lean): The hearty protein base that keeps the casserole filling and satisfying.
- 30 buttery crackers, crushed: Acts as a tender binder for the meatloaf, keeping it moist without heaviness.
- 1 (2-ounce) packet of onion soup mix: Infuses savory, rich onion flavor into the meatloaf mixture.
- 2 large eggs: Helps hold everything together with a light, fluffy texture.
- 3 cups macaroni pasta: Provides comforting carbs and a soft, chewy contrast to the meat.
- 2 cups milk: Creates a creamy base for the cheese sauce that coats the macaroni.
- 1 (10.5-ounce) can of condensed cheddar cheese soup: Delivers deep cheesy flavor and velvety texture to the sauce.
- 1 teaspoon salt: Enhances all the layers of flavor without overpowering.
- 1 teaspoon black pepper: Adds a gentle, warming spice to balance the richness.
- 1 tablespoon garlic powder: Introduces a subtle robust note that complements beef beautifully.
- 1 tablespoon onion powder: Boosts the savory depth throughout the casserole.
- 4 cups shredded mozzarella and cheddar cheese, divided: Creates a bubbly, golden cheesy crust and luscious interior melt.
How to Make Meatloaf Mac Casserole Recipe
Step 1: Prepare Your Oven and Baking Dish
Preheat your oven to 350 degrees Fahrenheit and grease a 9×13-inch baking dish thoroughly. This ensures your meatloaf layer won’t stick and sets the stage for a perfectly baked casserole that releases easily onto your plate.
Step 2: Mix the Tangy Sauce
In a medium bowl, combine 1 cup of ketchup and 1 cup of barbecue sauce. This simple yet flavorful mix will top the meatloaf, adding a glossy, tangy coating that caramelizes beautifully in the oven.
Step 3: Make the Meatloaf Base
In a large bowl, combine the ground beef, crushed crackers, onion soup mix, and eggs. Mix gently until all the ingredients are evenly incorporated. Spread this mixture evenly into your prepared baking dish, forming a uniform layer that will serve as the savory foundation for your casserole.
Step 4: Add the Sauce to the Meatloaf
Pour the ketchup and barbecue sauce mixture over the meatloaf layer, spreading it evenly to coat the surface. This topping not only locks in moisture but also gives the meatloaf a vibrant, irresistible glaze.
Step 5: First Bake
Bake the meatloaf layer in your preheated oven for 30 minutes. This allows the meat to cook through while the sauce starts to set into that perfect sticky, flavor-packed crust we all crave.
Step 6: Cook the Macaroni
While the meatloaf bakes, cook the macaroni pasta according to package instructions until al dente. Drain it well and set it aside—soon it will be enveloped in a creamy, cheesy sauce that will take the casserole to the next level.
Step 7: Prepare the Cheese Sauce
In a large bowl, whisk together the milk and the cheddar cheese soup. Stir in salt, black pepper, garlic powder, and onion powder to create a flavorful, smooth base that will marry the macaroni and cheese perfectly.
Step 8: Combine Macaroni and Cheese
Add the cooked macaroni to the cheese sauce mixture and mix in 2 cups of your shredded mozzarella and cheddar cheese blend. This gooey mixture is what makes the topping irresistibly rich and creamy.
Step 9: Assemble the Casserole
Pour the cheesy macaroni mixture over your partially baked meatloaf in the baking dish, spreading it out evenly. Then sprinkle the remaining 2 cups of shredded cheese on top—this will create that golden, bubbly finish everyone loves.
Step 10: Final Bake
Return the casserole to the oven and bake for an additional 17 to 20 minutes, or until the cheese on top has melted and started to brown slightly. This step gives the dish a perfect balance of melted, gooey cheese with a little bit of toasty crispness.
Step 11: Rest Before Serving
Once out of the oven, let the Meatloaf Mac Casserole Recipe cool for 5 to 10 minutes. This rest time helps everything set nicely and makes serving easier, while giving you a moment to admire that deliciously golden top.
How to Serve Meatloaf Mac Casserole Recipe

Garnishes
To elevate your serving, consider sprinkling freshly chopped parsley or green onions on top. These add a pop of color and a burst of freshness that perfectly complements the rich, meaty, cheesy layers underneath.
Side Dishes
This hearty casserole pairs wonderfully with simple, crisp sides like a green salad with vinaigrette or steamed broccoli. The greens balance the richness and add a refreshing contrast that cleanses the palate between bites.
Creative Ways to Present
For a fun twist, try serving the Meatloaf Mac Casserole Recipe in individual ramekins for personalized portions that look charming and let guests enjoy their own cheesy meatloaf creation. Alternatively, add a crunchy breadcrumb topping before baking for extra texture and flavor.
Make Ahead and Storage
Storing Leftovers
Store any leftover Meatloaf Mac Casserole Recipe in an airtight container in the fridge for up to 3 days. The flavors will mellow and blend even more, making for delicious meals on busy days.
Freezing
This casserole freezes beautifully. To freeze, let it cool completely, cover tightly with foil or plastic wrap, and place in the freezer for up to 2 months. Thaw in the refrigerator overnight before reheating.
Reheating
Reheat leftovers in the oven at 350 degrees Fahrenheit for about 15-20 minutes, or until warmed through and bubbly. You can also microwave individual servings, covering loosely to retain moisture and prevent drying out.
FAQs
Can I use different types of pasta in this Meatloaf Mac Casserole Recipe?
Absolutely! While macaroni is traditional, you can substitute elbow macaroni with small shells, rotini, or penne. Just make sure they cook to al dente and hold the cheese sauce well.
Is it possible to make this dish with ground turkey or chicken?
Yes, lean ground turkey or chicken can be used instead of ground beef for a lighter option. Just keep an eye on the baking time since these meats cook a bit faster and can dry out more easily.
What make-ahead options do I have for this casserole?
You can assemble the entire casserole the day before, keep it covered in the refrigerator, and then bake it fresh when ready to serve. This makes it a great option for stress-free weeknight dinners.
How spicy is this Meatloaf Mac Casserole Recipe?
This recipe is mild and flavorful rather than spicy. However, if you like a bit of heat, consider adding a pinch of cayenne pepper or hot sauce to the cheese sauce or meatloaf mixture.
Can I add vegetables to this casserole?
Definitely! You can stir in cooked vegetables like peas, diced bell peppers, or mushrooms into the macaroni-cheese mixture to boost nutrition and add extra texture.
Final Thoughts
There’s something truly special about the way this Meatloaf Mac Casserole Recipe brings together familiar flavors into one delightfully cozy dish. It’s perfect for family dinners, potlucks, or anytime you want a meal that tastes like pure comfort. I can’t wait for you to try it and discover just how easy and satisfying this heartwarming casserole can be!
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Meatloaf Mac Casserole Recipe
- Total Time: 1 hour 10 minutes
- Yield: 6 servings 1x
Description
Meatloaf Mac Casserole is a hearty, comforting dish combining classic meatloaf flavors with creamy, cheesy macaroni. This layered casserole features seasoned ground beef topped with a tangy ketchup-barbecue sauce, baked to perfection, then covered with cheesy macaroni and baked again until bubbly and golden. Perfect for family dinners, this dish is filling and flavorful with a satisfying mix of textures.
Ingredients
Sauce
- 1 cup ketchup, separated
- 1 cup barbecue sauce
Meatloaf
- 2 pounds lean ground beef
- 30 buttery crackers, crushed
- 1 (2-ounce) packet onion soup mix
- 2 large eggs
Macaroni and Cheese
- 3 cups macaroni pasta
- 2 cups milk
- 1 (10.5-ounce) can condensed cheddar cheese soup
- 1 teaspoon salt
- 1 teaspoon black pepper
- 1 tablespoon garlic powder
- 1 tablespoon onion powder
- 4 cups shredded mozzarella and cheddar cheese, divided
Instructions
- Preheat and prepare baking dish: Preheat your oven to 350°F. Grease a 9×13-inch baking dish to prevent sticking.
- Mix the sauce: In a medium bowl, combine 1 cup of ketchup with 1 cup of barbecue sauce until well blended.
- Prepare meatloaf mixture: In a large bowl, mix together the ground beef, crushed buttery crackers, onion soup mix, and eggs until fully incorporated. Spread this mixture evenly into the prepared baking dish.
- Top meatloaf with sauce: Spoon and spread the ketchup-barbecue sauce mixture evenly over the meatloaf layer in the baking dish.
- Bake the meatloaf: Place the baking dish in the preheated oven and bake for 30 minutes to cook the meatloaf partially.
- Cook macaroni: While the meatloaf bakes, cook the macaroni pasta according to package directions until al dente. Drain and set aside.
- Make cheese sauce: In a large bowl, whisk together the milk and condensed cheddar cheese soup until smooth. Add salt, pepper, garlic powder, and onion powder and whisk to combine the seasoning into the sauce.
- Combine macaroni and cheese sauce: Stir the cooked macaroni into the cheese sauce mixture thoroughly. Then mix in 2 cups of the shredded mozzarella and cheddar cheese evenly.
- Assemble casserole: Pour the cheesy macaroni mixture over the baked meatloaf layer and spread evenly. Then sprinkle the remaining 2 cups of shredded cheese over the top.
- Bake again: Return the casserole to the oven and bake for an additional 17-20 minutes, or until the cheese on top is melted and beginning to brown.
- Cool and serve: Remove the casserole from the oven and let it cool for 5-10 minutes before serving to allow it to set and make serving easier.
Notes
- You can substitute the crushed buttery crackers with breadcrumbs or crushed saltine crackers if preferred.
- Using lean ground beef helps reduce excess grease; drain if needed before assembling.
- Feel free to mix cheddar and mozzarella in any ratio you like for different flavors and melt quality.
- To make it spicier, add a pinch of cayenne pepper or some diced jalapeños to the cheese sauce.
- Letting the casserole rest before serving helps it hold together for neater slices.
- Prep Time: 20 minutes
- Cook Time: 50 minutes
- Category: Casserole
- Method: Baking
- Cuisine: American